Scientist/Sr. Scientist - Discovery Team

Company: Montara Therapeutics, Inc.
Location: San Francisco
Posted on: November 1, 2024

Job Description:

Scientist/Sr. Scientist - Discovery TeamAbout Montara Therapeutics, Inc.Montara Therapeutics, Inc. is a San Francisco-based preclinical-stage biopharmaceutical company pursuing novel approaches to develop safer and more efficacious treatments for neurological diseases. Montara's BrainOnly platform allows brain-specific pharmacology utilizing existing and novel chemical warheads, restricting deleterious on-target off-tissue peripheral activity.The company is backed by top-tier investors, including SV Health Investors' Dementia Discovery Fund, Two Bear Capital, KdT Ventures, and Dolby Family Ventures. For more information, visit montaratx.com.At Montara, we prioritize employee growth and well-being, fostering an environment of education, innovation, collaboration, and resilience. Our core values are Drive, Attention to Detail, Data Focus, and Empathy.About the PositionThe mission of Montara Therapeutics is to develop innovative therapies for diseases of the brain by leveraging our proprietary BrainOnly platform to enhance drug safety and efficacy and enable the drugging of targets previously considered undruggable. Many promising drug candidates for neurological or neurodegenerative diseases fail to advance due to dose-limiting, off-tissue peripheral toxicities, which impede both safety and efficacy.The Scientist/Sr. Scientist in the Discovery and Biomarkers team will play a pivotal role in both our biomarker and discovery efforts. This position offers an exciting opportunity to contribute to groundbreaking research and help shape the future of medicine.Job Requirements:

• Develop, optimize, and execute assays to test compounds for potency and target engagement in in vitro screening assays.
• Develop, optimize, and execute assays to test for potency and target engagement in tissues of animals dosed with our compounds.
• Train and help manage Research Associates and others to work in the Biomarker and Discovery programs.
• Work closely with the in vivo and chemistry teams in animal experiments and screening efforts.
• Make key decisions such as which biomarkers to pursue, what technologies to use, which tissues/biofluids to test, etc.
• Stay up-to-date with the latest literature in the field, review literature, plan experiments, and write up comprehensive reports for experiments performed in the electronic lab notebook.
• Stay up-to-date with new developments in the biomarker and drug screening fields, and implement new technologies.
• Manage several projects simultaneously.
• Design and execute biomarker strategies to support clinical programs.
• Create clear and succinct presentations summarizing the data generated.Qualifications:
• Ph.D. in a relevant scientific field (for Scientist), with 2-5 years of full time work experience (for Sr. Scientist) in cell-based screening and biomarker development in the pharmaceutical or biotech industry.
• Experience in optimizing a variety of cell-based and cell-free screening assays.
• Experience in generating knock-out and knock-in cell lines using CRISPR.
• Experience in cloning / custom plasmid generation.
• Experience with high-sensitivity biomarker assays such as MSD, alphaLISA, SMCxPRO, and Quanterix.
• Experience with FACS, immunofluorescence imaging, Western blotting, and plate-based assays.
• Experience in developing and validating biomarker assays in terms of parallelism, dilution linearity, spike recovery, specificity, precision, etc.
• Experience with biomarker and drug screening data analysis plans, including data interpretation and reporting.
• Experience in project management and cross-functional team leadership.
• Strong communication and interpersonal skills.
• Excellent organizational skills.
• Ability to manage multiple projects and prioritize effectively in a fast-paced environment.Salary & BenefitsThe total expected base salary for this role is $120,000-$145,000.Annual bonus opportunities.Stock options (amount TBD).Full medical, dental, and vision coverage for employees and their dependents.Matching 401k plans.Flexible PTO.Application InstructionsApplicants are invited to use the link below to submit their resumes and cover letters with a short paragraph (3-5 sentences) describing their specific experiences related to this position.Montara is an equal opportunity employer and will consider all qualified applicants for employment. Researchers from underrepresented groups are especially encouraged to apply.
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Keywords: Montara Therapeutics, Inc., San Jose , Scientist/Sr. Scientist - Discovery Team, Other , San Francisco, California